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Scoliosis secondary to osteoid osteoma: A case report of delayed diagnosis and 5-year follow-up

Our case of study is a 17 years old female patient who presented with painful scoliosis secondary to osteoid osteoma. The patient remained undiagnosed for years complaining of non-subsiding lumbar pain. Three years later, a thorough physical assesment and advanced radiological examination revealed that the patient’s complaint was related to an osteoid osteoma accompanying scoliosis. Surgical resection, fusion and instrumentation were applied.

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The effect of Urtica Urens on A549 lung cancer cell line

Aim: Urtica Urens is expected to produce effective results in reducing cancer cell growth as it exhibits anti-oxidant properties. The present study aims to investigate the effect of Urtica Urens on A549 lung cancer cell line. 

Material and Methods: Leaves of Urtica Urens were obtained from a local market and its freeze-dried mixture was stored at -20ºC. A549 lung cancer cells were incubated with either 5 or 10 µg/ml of aqueous extract of dried leaves or freeze-dried leaves preparations of Urtica Urens for 24 hours. The obtained data were analyzed using Graph Pad Prism software version 6. 

Results: The freeze-dried Urtica Urens showed a significant rise in late apoptosis phase and necrosis, respectively, as compared to the use of 5 µg/ml of aqueous extract of dried and the freeze-dried Urtica Urens. The cells were arresting either in G0/G1 phase (in freeze-dried leaves extract) or in G2/M phase (in dried leaves extract), under 10µg/ml concentration. 

Discussion: Urtica Urens was significantly producing more cellular and mitochondrial ROS, as compared to the untreated A549 cells control. The study concluded that cytotoxic effects are produced by dried extracts of Urtica Urens leaves on cancer cell lines, under certain concentrations.

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Two methods in bladder neck stenosis treatment efficiency: Holmium YAG laser and cold blade incision

Aim: In this study, we aimed to compare the efficacy of Holmium YAG laser (Ho YAG) and cold knife incision in the literature.

Material and Methods: Bladder neck stenosis was retrospectively screened in our hospital between January 2018 and January 2019. Recurrence time was defined as the maximum flow rate below 15 ml/s and/or when it became symptomatic. The patients were divided into two groups. The first group consisted of 14 patients with bladder neck stenosis who underwent cold knife procedure. The second group consisted of 17 patients with bladder neck stenosis who underwent Holmium laser.

Results: In the group where laser ablation was applied due to bladder neck stenosis, the postoperative 6th month maximum flow rate was significantly higher (p =, 001), while post voiding residual (PVR) values were significantly lower (p = 0.029). When the groups were compared in terms of flow rate and PVR, there was no significant difference in terms of urine flow rate and PVR at 3 months, respectively. Nevertheless, the flow rate and PVR amount at 6 months were statistically significant in favor of the laser ablation group.

Discussion: The use of holmium laser for bladder neck stenosis is promising in first-line treatment protocols with minimally invasive treatment modality, high success rates, low recurrence, and complication rates.

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