Search results

Comparison of the PT/INR Assay with Using two Different Reagent:Quikcoag PT and Technoplastin HIS on Ceveron Alpha Coagulation Analyzer

Aim: The Prothrombin time (PT) assay is a coagulation test that shows the activation of the extrinsic and final common pathways. The purpose of the present study was to evaluate the PT/INR levels using BioMedica QuikCoag PT and Technoclone Technoplastin HIS (heparin-insensitive) reagents on Ceveron alpha coagulation instrument.

Materials and Methods: The study was conducted in the Usak State Hospital in the west of Turkey. We analyzed 78 patients plasma PT/INR levels utilizing two kits on Ceveron alpha automated coagulation instrument.

Results: The mean age of 32 male 46 female patients was 51 ± 21. The mean value of PT was 14,77 ± 5,80 with Technoplastin HIS and 20,66 ±  12,19 with QuikCoag PT. The mean value of INR was 1,42 ± 0,65 with Technoplastin HIS and 1,67 ± 1,16 with QuikCoag PT. We obtained a statistically significant difference between PT and INR levels using a two-sample t-test (p=0,000 and p=0,000 respectively).

Discussion: Technoplastin HIS PT is a standardized Ca-thromboplastin reagent obtained from the rabbit brain. The values attained utilizing Quik Coag PT kits are not equal to those attained utilizing the Technoplastin HIS PT kits. An independent check of a producer’s international sensitivity index (ISI) assignments by a national reference laboratory in Turkey is also proposed.

Download attachments:

The Effect of the Use of Herbal Supply on Daily Life Activities Containing OTC (Chondroitin Sulfate + Glucosamine) in Patients with Knee Osteoarthritis

Aim: In this study, we aimed to compare pain, functional capacity, and quality of life of patients with knee osteoarthritis (OA), determine the factors affecting them, and investigate the effect of over-the-counter (OTC)-containing herbal supplementation on daily living activities in patients with knee OA. 

Materials and Methods: The study included 102 patients with the diagnosis of knee OA according to the American College of Rheumatology (ACR) criteria who were admitted to our orthopedics and traumatology outpatient clinic between March 2019 and September 2019.  Demographic data were recorded. The visual analog scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), medical outcomes study short-form health survey (SF-36) were used. The Kellgren-Lawrence scale was used for radiological evaluation. Information about the patients was determined by the questionnaire method and the patients were evaluated according to recruitment/exclusion criteria. In the study group, 102 patients with knee OA were included. On the other hand, 100 patients received a placebo as a control group. After three months of OTC supplementation, daily life activities and functional tests were performed and data were collected. Both subjective and objective data were calculated, compared, and analyzed. 

Results: It was observed that more than 80% of the patients with OA included in the study relieved pain with our food supplement components. There was an improvment in functional abilities of the patients with chronic OA as compared to standard medical treatment, and the pain level decreased significantly with test scores and scales after supplementary foods. The secondary endpoint was also noticed. We noticed that our subjects actually lost an average of 1.5 kg over the course of the study. 

Discussion: OA is the most common form of arthritis and the leading cause of disability among middle-aged and elderly people. We can develop theoretical strategies for primary prevention of joint damage through the reduction of obesity and joint trauma in particular. Effective chondroprotective therapies will be most useful when applied to high-risk individuals before the emergence of symptomatic OA.  

Conclusion: We concluded that food supplementation that was used in our study seemed to be beneficial in patients with knee ailments such as OA. It was equally interesting to observe that the majority of patients lost weight while taking these supplements.  Although the study was underpowered, it shed light on supplements containing glucosamine. We believe that further larger series studies in the near future can help us to obtain more objective findings.

Download attachments:

The Effect of Soft Tissue Mobilization on Pain, Disability Level, and Depressive Symptoms in Patients with Chronic Low Back Pain

Aim: In this study, we aimed to investigate the effect of soft tissue mobilization on pain, disability level, depressive symptoms and to determine the effect of sociodemographic data on the recovery level of patients with chronic non-specific low back pain. Materials and Methods: One hundred twenty-two participants (78 females, 44 males, mean age: 51.08 ± 10.78 years) were included in our randomized controlled study. Fifteen sessions (5 days a week; during 3 weeks) of conventional physiotherapy programme (hot-packs, TENS, therapeutic Ultrasound and exercise) were applied in both groups. Nine sessions (3 days a week; during 3 weeks) of soft tissue mobilization technique were performed additionally to the participants in Group 1. Pain intensity (Visual Analog Scale), disability level (Rolland Morris Disability Questionnaire), depressive symptoms (Beck Depression Scale) were examined before and after the treatment. Results: Decrease in pain intensity, disability level, and depressive symptoms were statistically significant in both groups (p < 0.001) after the treatment. As delta scores were compared, the significant difference between pain intensity and disability level (p < 0.05) was observed whereas reduction in depression level was not significant (p > 0.05).  Discussion: Soft Tissue Mobilization provides an additional benefit to the Conventional Physiotherapy program in reducing pain intensity and disability level in patients with chronic non-specific low back pain. 

Download attachments:
Page 1 of 534