The role of tobacco use in development of diabetes can easily be missed possibly in possibly in presence of other widely known risk factors. The following manuscript examines selected studies that explore the relationship between tobacco use and development of diabetes or glucose intolerance. The paper also describes the possible social factors relating to the issue while mentioning associated physiological and biochemical mechanisms that could connect diabetes with tobacco use or exposure. Furthermore, the aim is also to share the importance of different types of research methodologies e.g. quantitative or mixed/pragmatic types etc. in assessing a health issue.