Aim: The purpose of this study was to evaluate the necessity of radiological examinations of mentally handicapped (MHP) or uncooperative patients (UCP) with computed tomographic images obtained under intravenous sedation. Material and Method: A total of 98 MHPs or UCPs are included in this study. Radiological images were obtained with cone beam dental tomography (CBCT) under sedation anesthesia. Radiological and oral examinations were compared with each other and also with treatment results. Results: Radiological and oral indications of pediatric patients were 43.8% compatible, compared to 48% in adults. Radiological examination was 41.9% compatible with treatment results, while oral examination was 93.3% compatible in pediatric patients. In adult patients, radiological examination was 53% compatible with treatment results, while oral examination was 91.8% compatible. Discussion: Radiological examination alone is insufficient in treatment planning for MHPs/UCPs, but it does support the oral examination. Nevertheless, to avoid patients receiving general anesthesia more than once, CBCT imaging under sedation anesthesia seems to be the best method of radiological examination. For this purpose, to provide the best care to these patients, the number of dental clinics that have CBCT, an anesthesiologist, and a post-operative care unit and trained crew should be increased.