The evaluation of bone mineral density in patients with thalassemia major

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Aim: We aim to evaluate osteopathy in patients with thalassemia major (TM) by performing bone mineral densitometry (BMD) and biochemical indices and to emphasize preventive measures and the importance of early diagnosis of osteoporosis. Material and Method: 37 TM patients (18 female, 19 male) were included in the study. The age, gender, biochemical parameters were recorded. BMD was determined using dual energy X-ray absorptiometry from lumbar vertebrae. Z scores were calculated automatically by the device. According to Z scores; <-1 was normal, -1-2 was osteopenia, >-2 was considered as osteoporosis. Results:  9 patients’ Z scores (24.3%) were normal, 5 patients were osteopenic (13.5%), and 23 patients were osteoporotic (62.2%). In the osteoporotic group, parathyroid hormone (PTH) was low in 2 patients (5.4%) and vitamin D was deficient in 12 (32.4%) patients. Lumbar BMD was positively correlated with age (r=0.625, P=0.000), height (r = 0.759, P =0.000), weight (r=0.830, P=0.000), and BMI (r=0.730, P=0.000), and was negatively correlated with ALP (r=-0.422, P=0.010). In the osteopenic group, vitamin D was deficient in 2 patients (5.4%); all other biochemical parameters were within normal limits. Lumbar BMD was positively correlated with age (r=0.625, P=0.000), height (r=0.759, P=0.000), weight (r=0.830, P=0.000), and body mass index (BMI) (r=0.730, P= 0.000), and was negatively correlated with alkaline phosphatase (ALP) (r= -0.422, P= 0.010). Discussion: Despite regular transfusions, osteopathy may occur at high rates in patients with thalassemia.

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  • Recieved: 03.03.2016
  • Accepted: 08.03.2016
  • Published Online: 08.03.2016
  • Printed: 01.05.2016
  • DOI: 10.4328/AEMED.82
  • Author: Esra Akyüz Özkan, Zeynep Tuba Özdemir, Ayşe Neslin Akkoca
  • Identifier: J Ann Eu Med 2016;4(2): 26-30
  • Index Page: 26-30
  • How to Cite: Esra Akyüz Özkan, Zeynep Tuba Özdemir, Ayşe Neslin Akkoca. The evaluation of bone mineral density in patients with thalassemia major. J Ann Eu Med 2016;4(2): 26-30
  • Running Title: Bone Mineral Density in Thalasemic Patients
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