The treatment strategy for tibial fractures differs with fracture location, displacement, soft tissue condition and comminution. Intramedullary nailing is considered the gold standard treatment for tibial fractures. In this study, the functional and radiographic results of tibial shaft fractures repaired with the inflatable intramedullary nail method were evaluated. From 2013 to 2015, 17 patients (10 males, 7 females; 8 right, 9 left; mean age 40.7 years) with closed tibial fractures repaired with inflatable intramedullary nails were assessed. The time from injury to surgery was an average of 2 days (range, 0–6 days). The mean time of hospital stay was 6 days (range, 2–19 days). The mean follow-up time was 15.4 months (range, 9–25 months). The mean time for patients to return to normal daily activities was 4.5 months (range, 4–6 months). The mean operation time was 47.5 min (range, 35–80 min). None of the patients had major perioperative or postoperative complications such as deep vein thrombosis, fat embolism, infection, or neurovascular complications except for the occurrence of delayed union in one patient. Only 4 patients had anterior knee pain and ankle pain during the early postoperative period. Inflatable intramedullary nails seem to be safe and effective in the treatment of tibial AO/OTA type A and B midshaft fractures.