Aim: To compare the efficacy, safety of topiramate and extended-release divalproex sodium in migraine prophylaxis. Material and Method: Study groups consisted of 22 patients with chronic migraine, randomly administered 1000 mg extended-release divalproex sodium (first group), 21 patients given 100 mg topiramate (second group).Study was 28-week randomized, prospective trial including 4-week baseline, 4-week titration, 20-week maintenance phase. Primary efficacy measure…
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